A type of immune cell that has granules (small particles) with enzymes that are released during allergic reactions, asthma, anaphylaxis, atopic dermatitis and hay fever. A basophil is a type of white blood cell and a type of granulocyte. Basophilic granulocytes (usually referred to as basophils) are a small population of peripheral blood leukocytes containing cytoplasmatic granules that stain with basophilic dyes.
Basophils release histamine, bradykinin, and serotonin when activated by injury or infection. These substances are important to the inflammatory process since they increase capillary permeability and thus increase the blood flow to the affected area. Basophils are also involved in producing allergic responses. In addition, the granules on the surface of basophils secrete the natural anticoagulating substance, heparin. This provides some balance to the clotting and coagulation pathways.
Tissue basophils are called mast cells and are similar to blood basophils. Normally, mast cells are not found in peripheral blood and are rarely seen in healthy bone marrow. Basophil counts are used to study chronic inflammation. There is a positive correlation between high basophil counts and high concentrations of blood histamines, although this correlation does not imply cause and effect. It is extremely difficult to diagnose basopenia because a 1000–10,000 count differential would have to be done to get an absolute count.
SI units Conversion Calculator. Convert Basophils (BASO) level to %, Proportion of 1.0, Fraction. Clinical laboratory units online conversion from conventional or traditional units to Si units. Table of conversion factors for Basophils (BASO) unit conversion to %, Proportion of 1.0, Fraction.