CA 125 (Cancer Antigen 125)
These determinants are associated with a high molecular weight glycoprotein in serum and plasma of women with primary epithelial invasive ovarian cancer (excluding those with cancer of low malignant potential).
This assay is indicated for use as an aid in the detection of residual or recurrent ovarian carcinoma in patients who have undergone first‑line therapy and would be considered for second - look procedures. This assay is further indicated for serial measurement of CA 125 to aid in the management of cancer patients.
This assay is also intended to be used in conjunction with the HE4 assay as part of ROMA (Risk Of Ovarian Malignancy Algorithm) for the risk assessment of ovarian cancer in premenopausal and postmenopausal women presenting with pelvic mass.
CA 125 belongs to the family of hybridoma‑defined tumor markers. The values measured are defined by the use of the monoclonal antibody (MAb) OC 125.
CA 125 is found in a high percentage of non-mucinous ovarian tumors of epithelial origin3 and can be detected in serum.4,5 It does not occur on the surface epithelium of normal ovaries (adult and fetal). Ovarian carcinoma accounts for about 20 % of gynecological tumors; the incidence is 15/100000.
CA 125 has been found in the amniotic fluid and in the coelomic epithelium; both of these tissues are of fetal origin. In tissues of adult origin, the presence of CA 125 has been demonstrated in the epithelium of the oviduct, in the endometrium and in the endocervix.
Elevated values are sometimes found in various benign gynecological diseases such as ovarian cysts, ovarian metaplasia, endometriosis, uterus myomatosus or cervicitis. Slight elevations of this marker may also occur in early pregnancy and in various benign diseases (e.g. acute and chronic pancreatitis, benign gastrointestinal diseases, renal insufficiency, autoimmune diseases and others). Markedly elevated levels have been found in benign liver diseases such as cirrhosis and hepatitis. Extreme elevations can occur in any kind of ascites due to malignant and benign diseases. Although the highest CA 125 values occur in patients suffering from ovarian carcinoma, clearly elevated values are also observed in malignancies of the endometrium, breast, gastrointestinal tract, and various other malignancies.
Although CA 125 is a relatively unspecific marker, it is today the most important tumor marker for monitoring the therapy and progress of patients with serous ovarian carcinoma. At primary diagnosis the sensitivity of CA 125 depends on the FIGO stage (FIGO = Federation of Gynecology and Obstetrics); higher tumor stages are associated with higher CA 125 levels.
SI units Conversion Calculator. Convert CA 125 (Cancer Antigen 125) level to U/mL, kU/L . Clinical laboratory units online conversion from conventional or traditional units to Si units. Table of conversion factors for CA 125 (Cancer Antigen 125) unit conversion to U/mL, kU/L .